Dr. Mohamed Belhocine

Head of molecular Medicine Department and Director of al Jawhara Center

Department of Molecular Medicine

College of Medicine and Health Sciences


ramijy@agu.edu.bh
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Bio

     Dr. Mohamed Belhocine is the Head of Molecular Medicine Department and Director of the Jawhara Center. Mohamed is an Assistant Professor at Arabian Gulf University of Bahrain. Mohamed holds an MSc. in Microbiology from the University of Blida (Algeria), a bachelor’s degree in cell and molecular biology and an MSc. in bioinformatics, genomics and structural biochemistry and a PhD. of Bioinformatics and Genomics from Luminy university (France).  His research focuses on the application large-scale genomic approaches to understand epigenetic mechanisms associated with development of normal and leukemic lymphoid cells. Through his experience in laboratories as the Center of Immunology Marseille Luminy (CIML) and the Technological Advances for Genomics and Clinics Laboratory (TAGC), Mohamed has acquired extensive knowledge in experimental and computational biology, specifically in transcriptome analysis and chromatin immuno-precipitation coupled with deep sequencing (CHIP-Seq) and RNA-sequencing analysis. Mohamed is proficient in R, python, and JAVA. Mohamed is currently a Senior Bioinformatician at Jawhara center, where he supervises a clinical NGS analysis. Additionally, Mohamed develops and oversees research training programs in a few Algerian Universities. 

Academic Background
  • Ph.D. Bioinformatics and Genomics, Aix-Marseille University – France, 2016. 
  • M.Sc. Bioinformatics, Genomics and Structural biochemistry, Aix-Marseille University – France, 2012. 
  • B.Sc. Cell and Molecular Biology, Aix-Marseille University – France 2010. 
  • B.Sc. Microbiology, Saad Dahleb University – Algeria, 2005. 
Research Interests
Selected Publications
  1. Latiri M*, Belhocine M*, Smith C, Garnier N, Balducci E, Pinton A, et al. DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma. J Pathol. 2024; [Epub Sep 27].
  2. Belhocine M, Simonin M, Abad Flores JD, Cieslak A, Manosalva I, Pradel L, et al. Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes. Genome Res. 2022;32(6):[Epub Jun].
  3. Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, et al. Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study. J Clin Oncol. 2017;35(24):[Epub Jun].
  4. Renou L, Boelle PY, Deswarte C, Spicuglia S, Benyucef A, Calvo J, et al. Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia. Blood. 2017;129(15):[Epub Apr].
  5. Trinquand A, dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, et al. Triggering the TCR developmental checkpoint activates a therapeutically targetable tumor suppressive pathway in T-cell leukemia. Cancer Discov. 2016;6(6):[Epub Jun].