Dr. Mohamed Belhocine

Assistant Professor of Bioinformatics and Genomics

Department of Molecular Medicine

College of Medicine and Health Sciences


ramijy@agu.edu.bh
البريد الإلكتروني
السيرة الذاتية تحميل
الباحث العلمي (جوجل)
 
مختصر السيرة الذاتية

Mohamed is an Assistant Professor of Bioinformatics and Genomics at the Department of Molecular Medicine, Arabian Gulf University. He also develops and oversees research training programs in several Algerian universities. His research focuses on large-scale genomic approaches to uncover genetic and epigenetic mechanisms driving both normal and pathological cell development. He has identified dysregulated long non-coding RNAs (lncRNAs) in leukemia and studied their roles in cancer progression. Mohamed’s work also includes evaluating enhancer activity in various cellular contexts and exploring histone modification dynamics during early T cell development. His projects were conducted in collaboration with the European Blueprint consortium. In addition to his experimental and computational biology expertise, including transcriptome analysis, ChIP-Seq, and RNA sequencing, Mohamed has authored several high-impact articles. He has also collaborated extensively with renowned research institutes such as TAGC and Necker Institute, contributing significantly to large-scale genomic projects and advancing cancer research. 

التعليم الأكاديمي
  • Ph.D. Bioinformatics and Genomics, Aix-Marseille University – France, 2016. 
  • M.Sc. Bioinformatics, Genomics and Structural biochemistry, Aix-Marseille University – France, 2012. 
  • B.Sc. Cell and Molecular Biology, Aix-Marseille University – France 2010. 
  • B.Sc. Microbiology, Saad Dahleb University – Algeria, 2005. 
الإهتمامات البحثية
البحوث المختارة
  1. DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma.  The Journal of Pathology, 2024. 
  2. Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes. Genome Research, 2023. 
  3. A Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation. Journal of Experimental Medicine, 2021. 
  4. Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study. Journal of Clinical Oncology, 2017. 
  5. Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia. Cancer Discovery, 2016.